{"id":75,"date":"2016-06-13T17:49:27","date_gmt":"2016-06-13T17:49:27","guid":{"rendered":"http:\/\/ilyabiotech.com\/eng\/?page_id=75"},"modified":"2016-06-13T17:50:08","modified_gmt":"2016-06-13T17:50:08","slug":"nipt","status":"publish","type":"page","link":"http:\/\/ilyabiotech.com\/eng\/next-generation-sequencing\/nipt\/","title":{"rendered":"NIPT"},"content":{"rendered":"

NIPT \u2013 Early, Accurate and Risk free test for Down syndrome and Chromosomal abnormality<\/strong><\/p>\n

NIPT, which analyzes cell-free fetal DNA circulating in maternal blood, is a new option in the prenatal screening and testing paradigm for trisomies 21,18,13 and all other fetal chromosomal aneuploidies.
\nThe NIPT test provides an analysis of the fetal risk being affected with \u201cChromosomal Aneuploidies\u201d, by detecting fetal chromosomal materials with the new generation of high-throughput sequencing technology, combined with advanced bioinformatics analysis. This method is non-invasive, carries no risk of causing miscarriage and intrauterine infection and is highly sensitive with accuracy over 99.9%.<\/p>\n

The Science Behind NIPT<\/strong><\/p>\n

Cell-free DNA fragments (cfDNA) are short fragments of DNA, which can be found circulating in the blood. During pregnancy, cfDNA fragments originating from both the mother and fetus are present in the maternal blood circulation.
\nThe NIPT test requires taking a small maternal blood sample. cfDNA in the maternal blood is then analyzed with\u00a0the proprietary genetic sequencing technology and bioinformatics pipelines to screen for any chromosomal abnormality in the fetus. If any abnormality is present, small excesses or deficits in counts of the affected chromosome can be detected.
\nThe technology behind the NIPT test allows for highly accurate results with detection rates for the three most common trisomy conditions present at birth (Down Syndrome, Edwards Syndrome and Patau Syndrome) of over 99.5%. But it\u2019s important to understand that non-invasive prenatal tests such as NIPT are classified as screening tests. This means that they do not test with 100% accuracy, but the accuracy rate of NIPT is higher than amniocentesis.<\/p>\n

What do amniocentesis results mean?<\/h2>\n

Amniocentesis is a diagnostic test that detects chromosome abnormalities,\u00a0neural tube defects and genetic disorders with high levels of accuracy\u00a0(98-99%). \u00a0Although the probabilities of identification are high, this\u00a0test does not measure the severity of these birth defects (American pregnancy association: http:\/\/americanpregnancy.org\/prenatal-testing\/amniocentesis).<\/p>\n

Advantages of NIPT<\/strong><\/h2>\n